Polypharmacy Signal Atlas

MedTangle

List your medications and MedTangle scans every pair in the regimen, ranking which get co-reported with serious reactions in the FDA’s public data — worst first, as screening signals to raise with a pharmacist, never risk or advice.

22 drugs231 precomputed pairsopenFDA FAERS via api.fda.gov (public, no PHI)updated Jul 2, 2026

Signal atlas: 22 drugs, 207 signalled pairs, 114 with an interaction pattern. Ribbon thickness and colour show co-reporting signal strength; violet marks the rarer interaction-pattern pairs.Apixaban + Naproxen — co-reporting signal, peak omega 0.025 1.16, 1 reaction above thresholdClarithromycin + Trimethoprim — co-reporting signal, peak omega 0.025 1.24, 1 reaction above thresholdAtorvastatin + Sertraline — co-reporting signal, peak omega 0.025 1.35, 1 reaction above thresholdAtorvastatin + Metformin — co-reporting signal, peak omega 0.025 1.65, 1 reaction above thresholdAspirin + Atorvastatin — co-reporting signal, peak omega 0.025 1.97, 2 reactions above thresholdApixaban + Fluconazole — co-reporting signal, peak omega 0.025 1.97, 4 reactions above thresholdAspirin + Tramadol — co-reporting signal, peak omega 0.025 2.02, 1 reaction above thresholdClopidogrel + Tramadol — co-reporting signal, peak omega 0.025 2.09, 2 reactions above thresholdAspirin + Sertraline — co-reporting signal, peak omega 0.025 2.15, 2 reactions above thresholdAtorvastatin + Clarithromycin — co-reporting signal, peak omega 0.025 2.13, 3 reactions above thresholdClopidogrel + Atorvastatin — co-reporting signal, peak omega 0.025 2.22, 2 reactions above thresholdSimvastatin + Sertraline — co-reporting signal, peak omega 0.025 2.18, 3 reactions above thresholdSimvastatin + Methotrexate — co-reporting signal, peak omega 0.025 2.20, 2 reactions above thresholdLisinopril + Atorvastatin — co-reporting signal, peak omega 0.025 2.28, 2 reactions above thresholdSertraline + Ibuprofen — co-reporting signal, peak omega 0.025 2.23, 2 reactions above thresholdSimvastatin + Tramadol — co-reporting signal, peak omega 0.025 2.32, 2 reactions above thresholdDigoxin + Ondansetron — co-reporting signal, peak omega 0.025 2.31, 4 reactions above thresholdClopidogrel + Sertraline — co-reporting signal, peak omega 0.025 2.38, 5 reactions above thresholdOndansetron + Methotrexate — co-reporting signal, peak omega 0.025 2.37, 2 reactions above thresholdApixaban + Simvastatin — co-reporting signal, peak omega 0.025 2.42, 4 reactions above thresholdAspirin + Methotrexate — co-reporting signal, peak omega 0.025 2.48, 1 reaction above thresholdClopidogrel + Methotrexate — co-reporting signal, peak omega 0.025 2.49, 4 reactions above thresholdAspirin + Lisinopril — co-reporting signal, peak omega 0.025 2.54, 2 reactions above thresholdAspirin + Naproxen — co-reporting signal, peak omega 0.025 2.54, 2 reactions above thresholdApixaban + Trimethoprim — co-reporting signal, peak omega 0.025 2.56, 4 reactions above thresholdMetformin + Gemfibrozil — co-reporting signal, peak omega 0.025 2.56, 4 reactions above thresholdLisinopril + Sertraline — co-reporting signal, peak omega 0.025 2.60, 3 reactions above thresholdSpironolactone + Methotrexate — co-reporting signal, peak omega 0.025 2.64, 2 reactions above thresholdOndansetron + Trimethoprim — co-reporting signal, peak omega 0.025 2.64, 4 reactions above thresholdAspirin + Ondansetron — co-reporting signal, peak omega 0.025 2.72, 1 reaction above thresholdAtorvastatin + Trimethoprim — co-reporting signal, peak omega 0.025 2.70, 1 reaction above thresholdSpironolactone + Sertraline — co-reporting signal, peak omega 0.025 2.70, 5 reactions above thresholdMethotrexate + Clarithromycin — co-reporting signal, peak omega 0.025 2.71, 1 reaction above thresholdAspirin + Trimethoprim — co-reporting signal, peak omega 0.025 2.75, 2 reactions above thresholdLisinopril + Simvastatin — co-reporting signal, peak omega 0.025 2.75, 4 reactions above thresholdSertraline + Trimethoprim — co-reporting signal, peak omega 0.025 2.73, 3 reactions above thresholdAspirin + Ibuprofen — co-reporting signal, peak omega 0.025 2.79, 2 reactions above thresholdClopidogrel + Lisinopril — co-reporting signal, peak omega 0.025 2.80, 2 reactions above thresholdDigoxin + Linezolid — co-reporting signal, peak omega 0.025 2.83, 5 reactions above thresholdSpironolactone + Ondansetron — co-reporting signal, peak omega 0.025 2.89, 2 reactions above thresholdLisinopril + Gemfibrozil — co-reporting signal, peak omega 0.025 2.93, 5 reactions above thresholdSpironolactone + Naproxen — co-reporting signal, peak omega 0.025 2.94, 2 reactions above thresholdSertraline + Clarithromycin — co-reporting signal, peak omega 0.025 2.93, 4 reactions above thresholdNaproxen + Metformin — co-reporting signal, peak omega 0.025 2.90, 1 reaction above thresholdAspirin + Simvastatin — co-reporting signal, peak omega 0.025 2.97, 4 reactions above thresholdClopidogrel + Gemfibrozil — co-reporting signal, peak omega 0.025 2.99, 3 reactions above thresholdAmiodarone + Spironolactone — co-reporting signal, peak omega 0.025 2.99, 7 reactions above thresholdOndansetron + Metformin — co-reporting signal, peak omega 0.025 3.00, 1 reaction above thresholdWarfarin + Apixaban — co-reporting signal, peak omega 0.025 3.04, 3 reactions above thresholdOndansetron + Fluconazole — co-reporting signal, peak omega 0.025 3.07, 4 reactions above thresholdFluconazole + Clarithromycin — co-reporting signal, peak omega 0.025 3.07, 2 reactions above thresholdClopidogrel + Simvastatin — co-reporting signal, peak omega 0.025 3.14, 5 reactions above thresholdAtorvastatin + Spironolactone — co-reporting signal, peak omega 0.025 3.13, 3 reactions above thresholdSertraline + Metformin — co-reporting signal, peak omega 0.025 3.19, 5 reactions above thresholdLisinopril + Metformin — co-reporting signal, peak omega 0.025 3.22, 3 reactions above thresholdFluconazole + Trimethoprim — co-reporting signal, peak omega 0.025 3.26, 4 reactions above thresholdAtorvastatin + Gemfibrozil — co-reporting signal, peak omega 0.025 3.29, 3 reactions above thresholdClopidogrel + Digoxin — co-reporting signal, peak omega 0.025 3.38, 5 reactions above thresholdAspirin + Metformin — co-reporting signal, peak omega 0.025 3.39, 5 reactions above thresholdLinezolid + Trimethoprim — co-reporting signal, peak omega 0.025 3.42, 6 reactions above thresholdMethotrexate + Fluconazole — co-reporting signal, peak omega 0.025 3.51, 2 reactions above thresholdSpironolactone + Clarithromycin — co-reporting signal, peak omega 0.025 3.55, 5 reactions above thresholdClopidogrel + Apixaban — co-reporting signal, peak omega 0.025 3.63, 5 reactions above thresholdWarfarin + Methotrexate — co-reporting signal, peak omega 0.025 3.69, 1 reaction above thresholdAtorvastatin + Digoxin — co-reporting signal, peak omega 0.025 3.68, 3 reactions above thresholdAspirin + Spironolactone — co-reporting signal, peak omega 0.025 3.73, 5 reactions above thresholdMetformin + Trimethoprim — co-reporting signal, peak omega 0.025 3.76, 5 reactions above thresholdAspirin + Digoxin — co-reporting signal, peak omega 0.025 3.81, 5 reactions above thresholdAspirin + Gemfibrozil — co-reporting signal, peak omega 0.025 3.80, 4 reactions above thresholdSimvastatin + Metformin — co-reporting signal, peak omega 0.025 3.79, 7 reactions above thresholdClopidogrel + Metformin — co-reporting signal, peak omega 0.025 3.84, 6 reactions above thresholdAspirin + Clopidogrel — co-reporting signal, peak omega 0.025 3.92, 3 reactions above thresholdWarfarin + Tramadol — co-reporting signal, peak omega 0.025 3.94, 2 reactions above thresholdDigoxin + Sertraline — co-reporting signal, peak omega 0.025 3.94, 6 reactions above thresholdClopidogrel + Spironolactone — co-reporting signal, peak omega 0.025 4.01, 5 reactions above thresholdDigoxin + Trimethoprim — co-reporting signal, peak omega 0.025 4.05, 7 reactions above thresholdTramadol + Sertraline — co-reporting signal, peak omega 0.025 4.05, 1 reaction above thresholdDigoxin + Metformin — co-reporting signal, peak omega 0.025 4.08, 7 reactions above thresholdSimvastatin + Digoxin — co-reporting signal, peak omega 0.025 4.16, 4 reactions above thresholdSimvastatin + Spironolactone — co-reporting signal, peak omega 0.025 4.26, 7 reactions above thresholdSpironolactone + Trimethoprim — co-reporting signal, peak omega 0.025 4.39, 4 reactions above thresholdLisinopril + Spironolactone — co-reporting signal, peak omega 0.025 4.51, 6 reactions above thresholdDigoxin + Spironolactone — co-reporting signal, peak omega 0.025 4.60, 6 reactions above thresholdSpironolactone + Metformin — co-reporting signal, peak omega 0.025 4.64, 7 reactions above thresholdWarfarin + Atorvastatin — co-reporting signal, peak omega 0.025 4.70, 2 reactions above thresholdWarfarin + Metformin — co-reporting signal, peak omega 0.025 4.94, 3 reactions above thresholdWarfarin + Lisinopril — co-reporting signal, peak omega 0.025 5.15, 5 reactions above thresholdWarfarin + Clopidogrel — co-reporting signal, peak omega 0.025 5.25, 5 reactions above thresholdWarfarin + Spironolactone — co-reporting signal, peak omega 0.025 5.21, 6 reactions above thresholdWarfarin + Sertraline — co-reporting signal, peak omega 0.025 5.23, 6 reactions above thresholdWarfarin + Aspirin — co-reporting signal, peak omega 0.025 5.54, 4 reactions above thresholdWarfarin + Trimethoprim — co-reporting signal, peak omega 0.025 5.60, 4 reactions above thresholdWarfarin + Digoxin — co-reporting signal, peak omega 0.025 5.83, 6 reactions above thresholdAmiodarone + Naproxen — interaction pattern, peak omega 0.025 1.47, 2 reactions above thresholdAmiodarone + Fluconazole — interaction pattern, peak omega 0.025 1.55, 2 reactions above thresholdAmiodarone + Trimethoprim — interaction pattern, peak omega 0.025 1.61, 2 reactions above thresholdLinezolid + Gemfibrozil — interaction pattern, peak omega 0.025 1.65, 1 reaction above thresholdApixaban + Tramadol — interaction pattern, peak omega 0.025 1.74, 2 reactions above thresholdDigoxin + Tramadol — interaction pattern, peak omega 0.025 2.01, 4 reactions above thresholdAmiodarone + Methotrexate — interaction pattern, peak omega 0.025 2.06, 2 reactions above thresholdApixaban + Atorvastatin — interaction pattern, peak omega 0.025 2.29, 2 reactions above thresholdSertraline + Gemfibrozil — interaction pattern, peak omega 0.025 2.41, 2 reactions above thresholdApixaban + Clarithromycin — interaction pattern, peak omega 0.025 2.48, 1 reaction above thresholdAtorvastatin + Linezolid — interaction pattern, peak omega 0.025 2.49, 5 reactions above thresholdSimvastatin + Linezolid — interaction pattern, peak omega 0.025 2.46, 5 reactions above thresholdSertraline + Naproxen — interaction pattern, peak omega 0.025 2.49, 1 reaction above thresholdAmiodarone + Sertraline — interaction pattern, peak omega 0.025 2.52, 4 reactions above thresholdGemfibrozil + Clarithromycin — interaction pattern, peak omega 0.025 2.55, 1 reaction above thresholdAtorvastatin + Naproxen — interaction pattern, peak omega 0.025 2.67, 1 reaction above thresholdAmiodarone + Ibuprofen — interaction pattern, peak omega 0.025 2.72, 4 reactions above thresholdAtorvastatin + Simvastatin — interaction pattern, peak omega 0.025 2.78, 1 reaction above thresholdApixaban + Lisinopril — interaction pattern, peak omega 0.025 2.83, 5 reactions above thresholdSpironolactone + Gemfibrozil — interaction pattern, peak omega 0.025 2.83, 5 reactions above thresholdNaproxen + Clarithromycin — interaction pattern, peak omega 0.025 2.78, 2 reactions above thresholdGemfibrozil + Trimethoprim — interaction pattern, peak omega 0.025 2.79, 3 reactions above thresholdAtorvastatin + Tramadol — interaction pattern, peak omega 0.025 2.89, 2 reactions above thresholdTramadol + Clarithromycin — interaction pattern, peak omega 0.025 2.89, 3 reactions above thresholdAtorvastatin + Ondansetron — interaction pattern, peak omega 0.025 2.91, 1 reaction above thresholdAtorvastatin + Fluconazole — interaction pattern, peak omega 0.025 2.93, 1 reaction above thresholdApixaban + Sertraline — interaction pattern, peak omega 0.025 3.03, 3 reactions above thresholdLisinopril + Amiodarone — interaction pattern, peak omega 0.025 3.05, 4 reactions above thresholdSertraline + Fluconazole — interaction pattern, peak omega 0.025 3.00, 3 reactions above thresholdAspirin + Fluconazole — interaction pattern, peak omega 0.025 3.10, 2 reactions above thresholdApixaban + Ondansetron — interaction pattern, peak omega 0.025 3.09, 6 reactions above thresholdOndansetron + Ibuprofen — interaction pattern, peak omega 0.025 3.09, 2 reactions above thresholdLinezolid + Ibuprofen — interaction pattern, peak omega 0.025 3.09, 2 reactions above thresholdIbuprofen + Clarithromycin — interaction pattern, peak omega 0.025 3.10, 1 reaction above thresholdClopidogrel + Trimethoprim — interaction pattern, peak omega 0.025 3.14, 4 reactions above thresholdLisinopril + Clarithromycin — interaction pattern, peak omega 0.025 3.13, 5 reactions above thresholdOndansetron + Clarithromycin — interaction pattern, peak omega 0.025 3.12, 8 reactions above thresholdApixaban + Ibuprofen — interaction pattern, peak omega 0.025 3.17, 7 reactions above thresholdLinezolid + Naproxen — interaction pattern, peak omega 0.025 3.19, 4 reactions above thresholdNaproxen + Gemfibrozil — interaction pattern, peak omega 0.025 3.21, 2 reactions above thresholdDigoxin + Gemfibrozil — interaction pattern, peak omega 0.025 3.25, 5 reactions above thresholdTramadol + Fluconazole — interaction pattern, peak omega 0.025 3.28, 2 reactions above thresholdOndansetron + Naproxen — interaction pattern, peak omega 0.025 3.23, 1 reaction above thresholdAspirin + Linezolid — interaction pattern, peak omega 0.025 3.29, 8 reactions above thresholdLisinopril + Trimethoprim — interaction pattern, peak omega 0.025 3.32, 1 reaction above thresholdSimvastatin + Trimethoprim — interaction pattern, peak omega 0.025 3.29, 4 reactions above thresholdLisinopril + Naproxen — interaction pattern, peak omega 0.025 3.38, 1 reaction above thresholdSimvastatin + Ibuprofen — interaction pattern, peak omega 0.025 3.37, 2 reactions above thresholdSimvastatin + Naproxen — interaction pattern, peak omega 0.025 3.35, 2 reactions above thresholdDigoxin + Ibuprofen — interaction pattern, peak omega 0.025 3.34, 5 reactions above thresholdTramadol + Linezolid — interaction pattern, peak omega 0.025 3.38, 3 reactions above thresholdLinezolid + Methotrexate — interaction pattern, peak omega 0.025 3.38, 4 reactions above thresholdClopidogrel + Ondansetron — interaction pattern, peak omega 0.025 3.42, 2 reactions above thresholdClopidogrel + Naproxen — interaction pattern, peak omega 0.025 3.39, 2 reactions above thresholdDigoxin + Methotrexate — interaction pattern, peak omega 0.025 3.41, 3 reactions above thresholdSpironolactone + Ibuprofen — interaction pattern, peak omega 0.025 3.39, 3 reactions above thresholdMetformin + Fluconazole — interaction pattern, peak omega 0.025 3.41, 4 reactions above thresholdSpironolactone + Fluconazole — interaction pattern, peak omega 0.025 3.48, 6 reactions above thresholdClopidogrel + Ibuprofen — interaction pattern, peak omega 0.025 3.50, 3 reactions above thresholdApixaban + Linezolid — interaction pattern, peak omega 0.025 3.54, 4 reactions above thresholdLisinopril + Ibuprofen — interaction pattern, peak omega 0.025 3.53, 1 reaction above thresholdAtorvastatin + Amiodarone — interaction pattern, peak omega 0.025 3.52, 6 reactions above thresholdIbuprofen + Fluconazole — interaction pattern, peak omega 0.025 3.50, 1 reaction above thresholdLisinopril + Ondansetron — interaction pattern, peak omega 0.025 3.61, 1 reaction above thresholdAspirin + Amiodarone — interaction pattern, peak omega 0.025 3.61, 5 reactions above thresholdClopidogrel + Fluconazole — interaction pattern, peak omega 0.025 3.64, 4 reactions above thresholdApixaban + Digoxin — interaction pattern, peak omega 0.025 3.65, 5 reactions above thresholdApixaban + Methotrexate — interaction pattern, peak omega 0.025 3.66, 5 reactions above thresholdSpironolactone + Linezolid — interaction pattern, peak omega 0.025 3.65, 7 reactions above thresholdMetformin + Clarithromycin — interaction pattern, peak omega 0.025 3.64, 8 reactions above thresholdClopidogrel + Clarithromycin — interaction pattern, peak omega 0.025 3.67, 3 reactions above thresholdTramadol + Ondansetron — interaction pattern, peak omega 0.025 3.70, 3 reactions above thresholdOndansetron + Linezolid — interaction pattern, peak omega 0.025 3.71, 5 reactions above thresholdIbuprofen + Gemfibrozil — interaction pattern, peak omega 0.025 3.69, 1 reaction above thresholdNaproxen + Fluconazole — interaction pattern, peak omega 0.025 3.67, 1 reaction above thresholdApixaban + Amiodarone — interaction pattern, peak omega 0.025 3.75, 5 reactions above thresholdAtorvastatin + Ibuprofen — interaction pattern, peak omega 0.025 3.73, 2 reactions above thresholdSpironolactone + Tramadol — interaction pattern, peak omega 0.025 3.82, 4 reactions above thresholdOndansetron + Sertraline — interaction pattern, peak omega 0.025 3.81, 2 reactions above thresholdOndansetron + Gemfibrozil — interaction pattern, peak omega 0.025 3.83, 2 reactions above thresholdAspirin + Apixaban — interaction pattern, peak omega 0.025 3.86, 3 reactions above thresholdAspirin + Clarithromycin — interaction pattern, peak omega 0.025 3.85, 2 reactions above thresholdLisinopril + Fluconazole — interaction pattern, peak omega 0.025 3.84, 3 reactions above thresholdIbuprofen + Metformin — interaction pattern, peak omega 0.025 3.87, 2 reactions above thresholdGemfibrozil + Fluconazole — interaction pattern, peak omega 0.025 3.87, 2 reactions above thresholdLisinopril + Linezolid — interaction pattern, peak omega 0.025 3.92, 5 reactions above thresholdAmiodarone + Metformin — interaction pattern, peak omega 0.025 3.89, 8 reactions above thresholdClopidogrel + Amiodarone — interaction pattern, peak omega 0.025 4.00, 6 reactions above thresholdApixaban + Spironolactone — interaction pattern, peak omega 0.025 4.06, 5 reactions above thresholdLisinopril + Digoxin — interaction pattern, peak omega 0.025 4.13, 5 reactions above thresholdSimvastatin + Ondansetron — interaction pattern, peak omega 0.025 4.14, 2 reactions above thresholdDigoxin + Fluconazole — interaction pattern, peak omega 0.025 4.12, 7 reactions above thresholdLinezolid + Fluconazole — interaction pattern, peak omega 0.025 4.19, 8 reactions above thresholdLinezolid + Clarithromycin — interaction pattern, peak omega 0.025 4.22, 5 reactions above thresholdClopidogrel + Linezolid — interaction pattern, peak omega 0.025 4.32, 5 reactions above thresholdSimvastatin + Fluconazole — interaction pattern, peak omega 0.025 4.36, 3 reactions above thresholdApixaban + Metformin — interaction pattern, peak omega 0.025 4.49, 6 reactions above thresholdDigoxin + Clarithromycin — interaction pattern, peak omega 0.025 4.49, 3 reactions above thresholdDigoxin + Amiodarone — interaction pattern, peak omega 0.025 4.76, 7 reactions above thresholdWarfarin + Ondansetron — interaction pattern, peak omega 0.025 4.93, 3 reactions above thresholdWarfarin + Naproxen — interaction pattern, peak omega 0.025 5.01, 3 reactions above thresholdLinezolid + Metformin — interaction pattern, peak omega 0.025 5.23, 8 reactions above thresholdWarfarin + Gemfibrozil — interaction pattern, peak omega 0.025 5.42, 6 reactions above thresholdWarfarin + Ibuprofen — interaction pattern, peak omega 0.025 5.46, 4 reactions above thresholdWarfarin + Amiodarone — interaction pattern, peak omega 0.025 5.50, 4 reactions above thresholdWarfarin + Linezolid — interaction pattern, peak omega 0.025 5.56, 5 reactions above thresholdWarfarin + Simvastatin — interaction pattern, peak omega 0.025 5.60, 7 reactions above thresholdSimvastatin + Clarithromycin — interaction pattern, peak omega 0.025 5.64, 5 reactions above thresholdWarfarin + Fluconazole — interaction pattern, peak omega 0.025 6.17, 8 reactions above thresholdWarfarin + Clarithromycin — interaction pattern, peak omega 0.025 6.58, 6 reactions above thresholdSimvastatin + Amiodarone — interaction pattern, peak omega 0.025 5.99, 3 reactions above thresholdSimvastatin + Gemfibrozil — interaction pattern, peak omega 0.025 6.06, 5 reactions above thresholdAmiodarone + Ondansetron — interaction pattern, peak omega 0.025 6.33, 1 reaction above thresholdSertraline + Linezolid — interaction pattern, peak omega 0.025 6.48, 2 reactions above thresholdWarfarin — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.WarfarinApixaban — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.ApixabanAspirin — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.AspirinClopidogrel — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.Clopidogr…Ibuprofen — 17 signalled pairs, carries an interaction pattern. Click to add to the selection.IbuprofenNaproxen — 16 signalled pairs, carries an interaction pattern. Click to add to the selection.NaproxenClarithromycin — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.Clarithro…Fluconazole — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.Fluconazo…Trimethoprim — 17 signalled pairs, carries an interaction pattern. Click to add to the selection.Trimethop…Simvastatin — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.Simvastat…Atorvastatin — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.Atorvasta…Gemfibrozil — 17 signalled pairs, carries an interaction pattern. Click to add to the selection.Gemfibroz…Amiodarone — 17 signalled pairs, carries an interaction pattern. Click to add to the selection.AmiodaroneDigoxin — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.DigoxinOndansetron — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.Ondansetr…Spironolactone — 21 signalled pairs, carries an interaction pattern. Click to add to the selection.Spironola…Lisinopril — 19 signalled pairs, carries an interaction pattern. Click to add to the selection.LisinoprilSertraline — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.SertralineLinezolid — 20 signalled pairs, carries an interaction pattern. Click to add to the selection.LinezolidTramadol — 13 signalled pairs, carries an interaction pattern. Click to add to the selection.TramadolMetformin — 19 signalled pairs, carries an interaction pattern. Click to add to the selection.MetforminMethotrexate — 12 signalled pairs, carries an interaction pattern. Click to add to the selection.Methotrex…

Strongest signals in the 22-drug atlas

The 114 pairs carrying the rarer interaction pattern lead the ranking. Click any to explore it, or list your own medications above.

  • n=186
  • n=97
  • n=195
  • n=188
  • n=367
  • n=215
  • n=235
  • n=753

These are screening signals from spontaneous FAERS reports — confounded by co-prescription, not measures of risk, causation, or incidence, and not medical advice.

6 common medications that light up the whole watch-list

Does it actually work?

Recovering known interactions

MedTangle independently flagged 11 of 16 textbook drug interactions clinicians are taught to watch for — from the FDA’s raw adverse-event reports alone, across a 22-drug demo slice, with no interaction rules built in. 6 reached the rarer interaction-pattern tier.

  1. Expected:
  2. Expected:
  3. Expected:
  4. Expected:
  5. Expected:
  6. Expected:
  7. Expected:
  8. Expected:
  9. Expected:
  10. Expected:
  11. Expected:
  12. Apixaban & Fluconazole

    Fluconazole (CYP3A4/P-gp inhibition) raises apixaban levels and bleeding risk.

    ✗ not flagged
    Expected:
  13. Simvastatin & Amiodarone

    Amiodarone inhibits simvastatin's metabolism (CYP3A4); the FDA warns to limit the simvastatin dose.

    ✗ not flagged
    Expected:
  14. Amiodarone & Ondansetron

    Two QT-prolonging drugs — additive risk of a dangerous heart rhythm.

    ✗ not flagged
    Expected:
  15. Lisinopril & Trimethoprim

    Trimethoprim has a potassium-sparing effect; with an ACE inhibitor it can raise potassium dangerously.

    ✗ not flagged
    Expected:
  16. Methotrexate & Trimethoprim

    Both are antifolates; together they can suppress the bone marrow and drop all blood-cell counts.

    ✗ not flagged
    Expected:

The 5it didn’t flag are cases where that exact reaction had too few co-reports in this 22-drug demo slice to clear MedTangle’s conservative threshold. It prefers a miss to a false alarm — a false negative, not a false positive. More would surface on the full FDA drug set. That restraint is the point: it is what makes the 11 it did recover worth trusting.

Reading the scale

Signal strength

Bars and the gauge encode omega 0.025 — the conservative lower bound of a disproportionality score. Calm blue-grey means near the noise floor; amber to deep coral means increasingly co-reported beyond chance.

Co-reporting signal

A reaction shows up with this drug pair more than the database would produce by chance. It is confounded by co-prescription — a reason to look closer, not a verdict.

Interaction pattern

The rarer, stronger tier, shown in violet: the co-reporting excess sits beyond what each drug shows on its own.